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Statistical analysis

Amanida

An R package for quantitative and qualitative meta-analysis of metabolomics studies when only significance, effect-size, identifier, or direction information is available.

Platform-independentMetabolite profilingR packageOpen source
Access toolSuggest an update

Overview

Amanida combines study-level metabolomics results when individual measurements or variance estimates are unavailable. It performs significance/fold-change meta-analysis and qualitative trend vote-counting, with plots and reports for comparing results across studies.

What can this tool do?

Univariate statistics

Common uses

  • Combine metabolomics evidence across studies when variance data are unavailable.

Scientific fit

Primary function

Statistical analysis

Analysis types

Metabolite profiling

Data compatibility

Inputs

Statistical results, Compound list or annotations

Outputs

Statistical results

Input formats

CSV, TXT or Excel tables of study-level results and sample sizes

Output formats

R statistical/vote-count tables, volcano plots and rendered reports

Scope and considerations

Designed for

  • An R package for quantitative and qualitative meta-analysis of metabolomics studies when only significance, effect-size, identifier, or direction information is available.

Not designed for

  • Reprocessing raw MS data or removing heterogeneity and publication bias merely by pooling reported p-values.

Important requirements

  • R plus harmonized metabolite identifiers, study references and either p-values/fold changes/sample sizes or qualitative trend labels; input column order must follow the selected mode.

Considerations

  • Align metabolite identities and fold-change direction before combination. Study dependence, selective reporting and incompatible designs affect interpretation; optional identifier harmonization can query PubChem.

Access and documentation

Primary accessDocumentation

GPL-3.0 source distribution. External datasets, dependent packages and any hosted routes retain their own terms; software operation was not tested.

License: GPL-3.0

Evidence and review

Enveda intake rechecked against official repository documentation, package/license metadata and primary publication identity on 2026-10-27. Editorial source review only; no software execution or independent benchmark. See docs/enveda-expansion-review-2026-10-27-batch2.md.

Core publications

Resource papers, direct updates and tool-specific methods. Selection policy.

  1. Amanida: an R package for meta-analysis of metabolomics non-integral data. Bioinformatics (2021). doi:10.1093/bioinformatics/btab591

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Entry history

Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.

  1. 2026-10-27 · First committed entry

    Add 24 reviewed Enveda tools in a separate second batch

    View change · Entry at this revision

Full GitHub history