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Preprocessing and feature extraction

CAMERA

Group and annotate related LC-MS signals after XCMS peak detection.

LC-MSR packageOpen source
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Overview

CAMERA uses chromatographic relationships and isotope/adduct rules to organize peaks into compound-related groups. This can reduce redundant signals before interpretation.

What can this tool do?

Adduct and isotope grouping

Common uses

  • Annotate isotopes and adducts in XCMS peak lists.
  • Investigate groups of coeluting ion features.

Scientific fit

Primary function

Preprocessing and feature extraction

Data compatibility

Inputs

Feature or peak table, Mass spectra

Outputs

Feature or peak table, Compound list or annotations

Input formats

Other, XCMS peak-list objects

Output formats

Other, R annotation tables and pseudospectra

Scope and considerations

Designed for

  • Annotate isotopes and adducts in XCMS peak lists.

Not designed for

  • Confirming a unique chemical structure from an adduct assignment.

Important requirements

  • XCMS-generated peak lists and compatible R/Bioconductor versions.

Considerations

  • Coelution and correlation are imperfect evidence; inspect ambiguous groups and ionization-specific rules.

Access and documentation

Primary access

Open-source software; use the official installation, license and citation guidance for the selected release.

From tool to strategy

Strategies using CAMERA

Reference-pool discovery with cohort-wide signal extractionPhenotype association · Analytical Chemistry

Evidence and review

Documentation-based editorial review on 7 September 2026. Scope and limitations summarize the linked official sources; software execution and developer verification were not assessed.

Core publications

Resource papers, direct updates and tool-specific methods. Selection policy.

  1. Kuhl C, Tautenhahn R, Böttcher C, et al. CAMERA: an integrated strategy for compound spectra extraction and annotation of liquid chromatography/mass spectrometry data sets. Anal Chem 84, 283-289 (2012). doi:10.1021/ac202450g

Related tools

RAMClustRComplementary to · Cluster related mass-spectrometry features and export compound-level spectra and abundances.xcmsComplementary to · An open-source Bioconductor package for chromatographic mass spectrometry data preprocessing, feature detection, alignment, grouping, and visualization.Workflow4MetabolomicsComplementary to · Create and share metabolomics processing and analysis workflows in a Galaxy environment.

Entry history

Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.

  1. 2026-09-08 · Entry update

    Audit core publications across existing tools

    View change · Entry at this revision
  2. 2026-09-07 · First committed entry

    Add 50 documented metabolomics resources

    View change · Entry at this revision

Full GitHub history