Overview
LipidCreator calculates lipid precursor and fragment masses from user-defined lipid building blocks. It supports isotope-labelled targets and predicted spectral libraries, with direct Skyline integration or standalone use.
What can this tool do?
Common uses
- Prepare lipid transition lists for targeted acquisition.
- Generate predicted lipid fragment libraries for Skyline workflows.
Scientific fit
Primary function
Data acquisition and instrument control
Other functions
Spectral processing and comparison
Analysis types
Targeted metabolomics, Lipidomics
Data compatibility
Inputs
Compound list or annotations
Outputs
Spectral library, Human-readable report
Input formats
User-defined lipid classes, chains, adducts and fragments
Output formats
Precursor-product transition lists, BLIB spectral libraries
Scope and considerations
Designed for
- Assay design for supported lipid classes.
Not designed for
- Automatic proof that predicted transitions are selective in a biological matrix.
Important requirements
- Target lipid definitions and compatible runtime; Skyline for integrated workflows.
Considerations
- Validate transition selectivity and collision energies experimentally for the intended instrument.
Access and documentation
Install through the Skyline Tool Store or use the standalone application. Windows instructions are documented; Linux uses Mono with reported GUI limitations. Consult release-specific requirements.
License: MIT
Evidence and review
Official documentation and dedicated software publications reviewed on 2026-09-11. No installation, uploaded dataset or independent benchmark was run.
Core publications
Resource papers, direct updates and tool-specific methods. Selection policy.
- Peng B, Kopczynski D, Pratt BS, et al. LipidCreator workbench to probe the lipidomic landscape. Nature Communications 11, 2057 (2020). doi:10.1038/s41467-020-15960-z PMID 32345972
Related tools
Entry history
Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.
- 2026-09-11 · First committed entry
Complete supplied lipidomics group and prioritize Ask Navigator
View change · Entry at this revision