Overview
MetaboSignal merges and analyzes KEGG pathway information to study network topology and possible connections to metabolic phenotypes.
What can this tool do?
Common uses
- Overlay metabolite and gene candidates on a shared network.
- Investigate paths linking signaling genes to metabolites.
Scientific fit
Primary function
Multi-omics integration
Data compatibility
Inputs
Compound list or annotations, Pathway or reaction data
Outputs
Pathway or reaction data, Human-readable report
Input formats
Other, KEGG pathways and gene/metabolite identifiers
Output formats
Other, R graphs and network summaries
Scope and considerations
Designed for
- Overlay metabolite and gene candidates on a shared network.
Not designed for
- Interpreting network distance as demonstrated causal regulation.
Important requirements
- R, compatible pathway access and recognized gene/metabolite identifiers.
Considerations
- Topology depends on the underlying knowledgebase and identifier mapping; KEGG access and reuse terms apply separately.
Access and documentation
Bioconductor software; pathway-data licensing is separate.
Evidence and review
Documentation-based editorial review on 7 September 2026. Scope and limitations summarize the linked official sources; software execution and developer verification were not assessed.
Core publications
Resource papers, direct updates and tool-specific methods. Selection policy.
- Rodriguez-Martinez A, Ayala R, Posma JM, et al. MetaboSignal: a network-based approach for topological analysis of metabotype regulation via metabolic and signaling pathways. Bioinformatics 33, 773-775 (2017). doi:10.1093/bioinformatics/btw697
Related tools
Entry history
Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.
- 2026-09-08 · Entry update
Audit core publications across existing tools
View change · Entry at this revision - 2026-09-07 · First committed entry
Add 50 documented metabolomics resources
View change · Entry at this revision