Overview
WaveICA 2.0 uses wavelet decomposition and independent-component analysis to adjust inter- and intra-batch effects without requiring batch labels.
What can this tool do?
Common uses
- Correct injection-order-associated variation in untargeted metabolomics tables.
Scientific fit
Primary function
Normalization and batch correction
Analysis types
Untargeted metabolomics
Data compatibility
Inputs
Feature or peak table, Sample metadata
Outputs
Feature or peak table
Input formats
Sample-by-peak numeric matrix and corresponding injection-order vector
Output formats
R result list containing corrected data
Scope and considerations
Designed for
- WaveICA 2.0 uses wavelet decomposition and independent-component analysis to adjust inter- and intra-batch effects without requiring batch labels.
Not designed for
- Raw-file peak detection or recovery of biology irretrievably confounded with acquisition order.
Important requirements
- R with waveslim, ica, mgcv and the package dependencies.
- Reliable injection order aligned to each matrix row.
Considerations
- Review correction against QC samples and biological covariates; removal of order-associated variation can also remove confounded biological effects.
- Batch labels are not required, but injection-order metadata is required.
Access and documentation
Repository LICENSE grants MIT terms; DESCRIPTION inconsistently says License: No. Check the license file when reusing code. Not execution-tested.
License: MIT
Evidence and review
Enveda intake checked against official documentation, license information and primary DOI/title/year on 2026-10-22. Editorial review only; no execution or independent benchmark.
Core publications
Resource papers, direct updates and tool-specific methods. Selection policy.
- WaveICA 2.0: a novel batch effect removal method for untargeted metabolomics data without using batch information. Metabolomics (2021). doi:10.1007/s11306-021-01839-7
Related tools
Entry history
Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.
- 2026-10-23 · First committed entry
Add ten reviewed Enveda tools with input and applicability limits
View change · Entry at this revision