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Pathway and biological interpretation

BioPAN

LIPID MAPS web tool for exploring changes in mammalian lipid pathways and predicting relative reaction or enzyme activity from quantitative lipidomics data.

Platform-independentLipidomicsWeb applicationFree web service
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Overview

BioPAN compares quantitative mammalian lipidomics data within a curated reaction network. It highlights predicted pathway changes and associated enzymes, with optional LipidLynxX nomenclature conversion. These are abundance-based inferences, not direct flux measurements.

What can this tool do?

Pathway enrichmentNetwork visualization

Common uses

  • Compare lipid-class and molecular-species pathway patterns.
  • Prioritize possible enzyme-associated changes for follow-up.

Scientific fit

Primary function

Pathway and biological interpretation

Analysis types

Lipidomics

Data compatibility

Inputs

Feature or peak table, Compound list or annotations

Outputs

Pathway or reaction data, Statistical results, Human-readable report

Input formats

CSV or TSV

Output formats

JSON, JPEG/PNG/SVG pathway graphs, Text reaction scores and result tables

Scope and considerations

Designed for

  • Pathway exploration from quantitative mammalian lipidomics.

Not designed for

  • Direct measurement of enzyme activity or metabolic flux.
  • Oxidized-lipid analysis under the documented input restrictions.

Important requirements

  • CSV lipid concentrations with at least two conditions and two samples per condition.

Considerations

  • For sum-composition annotations, input order can affect which reaction combinations are retained.
  • Review nomenclature conversion and annotation resolution before interpreting the graph.

Access and documentation

Primary accessDocumentation

Hosted LIPID MAPS tool requiring no installation. Documentation states that analysis links remain available for 30 days; export results needed for long-term records.

Evidence and review

Official service documentation and dedicated tool citation reviewed on 2026-09-11. Included for downstream MS lipidomics interpretation. No user dataset was uploaded or enrichment analysis run.

Core publications

Resource papers, direct updates and tool-specific methods. Selection policy.

  1. Gaud C, Sousa BC, Nguyen A, et al. BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS. F1000Research 10, 4 (2021).

Related tools

LipidLynxXIntegrates with · Optional nomenclature conversion is documented in the BioPAN input workflow.LIPID MAPSPart of · Hosted by the LIPID MAPS Lipidomics Gateway.

Entry history

Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.

  1. 2026-09-11 · Entry update

    Add lipid naming tools and BioPAN integration

    View change · Entry at this revision
  2. 2026-09-11 · First committed entry

    Add lipid ontology and pathway interpretation tools

    View change · Entry at this revision

Full GitHub history