Metabolomics Navigator Tools, strategies & workflow guidance for metabolomics

Statistical analysis

lipidr

Analyze lipid abundance tables and test patterns across lipid classes and structural properties.

Platform-independentR packageOpen source
Access toolSuggest an update

Overview

lipidr supports inspection, normalization, differential analysis and lipid-set enrichment, including class, chain-length and unsaturation patterns.

What can this tool do?

Univariate statisticsMultivariate statisticsPathway enrichment

Common uses

  • Analyze targeted or untargeted lipidomics tables.
  • Investigate coordinated changes among related lipid species.

Scientific fit

Primary function

Statistical analysis

Data compatibility

Inputs

Feature or peak table, Sample metadata

Outputs

Statistical results, Human-readable report

Input formats

Other, Numeric matrix or Skyline export

Output formats

Other, R lipid-analysis objects, statistics and plots

Scope and considerations

Designed for

  • Analyze targeted or untargeted lipidomics tables.

Not designed for

  • Inferring positional lipid structures that were not resolved by the measurement.

Important requirements

  • A lipid abundance matrix or compatible Skyline export, with sample metadata and parseable lipid names.

Considerations

  • Lipid naming and structural resolution determine the sets available for enrichment; review ambiguous or unparsed entries.

Access and documentation

Primary access

Bioconductor package; consult its license and the separate terms of imported public datasets.

Evidence and review

Documentation-based editorial review on 7 September 2026. Scope and limitations summarize the linked official sources; software execution and developer verification were not assessed.

Core publications

Resource papers, direct updates and tool-specific methods. Selection policy.

  1. Mohamed A, Molendijk J, Hill MM. lipidr: A Software Tool for Data Mining and Analysis of Lipidomics Datasets. J Proteome Res 19, 2890-2897 (2020). doi:10.1021/acs.jproteome.0c00082

Software and documentation citations

Related tools

LIPID MAPSComplementary to · Find lipid structures, classifications, nomenclature guidance and lipidomics analysis resources.SkylineComplementary to · Develop and review targeted mass-spectrometry assays, including small-molecule quantification.LION/webComplementary to · Web-based lipid ontology enrichment tool that connects lipid lists or rankings to chemical, biophysical, cellular and functional lipid properties.

Entry history

Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.

  1. 2026-09-08 · Entry update

    Audit core publications across existing tools

    View change · Entry at this revision
  2. 2026-09-07 · First committed entry

    Add 50 documented metabolomics resources

    View change · Entry at this revision

Full GitHub history