Overview
LION/web interprets lipidomics through enrichment of lipid ontology terms. These terms cover chemical and biophysical properties and biological associations, rather than only metabolic pathways. The service operates downstream of lipid identification and quantification.
What can this tool do?
Common uses
- Identify lipid properties enriched among changed species.
- Interpret ranked quantitative lipidomics results.
Scientific fit
Primary function
Pathway and biological interpretation
Analysis types
Lipidomics
Data compatibility
Inputs
Compound list or annotations, Feature or peak table, Statistical results
Outputs
Statistical results, Human-readable report
Input formats
CSV or TSV, Lipid lists or rankings, depending on analysis mode
Output formats
Ontology enrichment results and interactive reports
Scope and considerations
Designed for
- Ontology-based interpretation of annotated lipidomics data.
Not designed for
- Raw MS processing or proving pathway activity from enrichment alone.
Important requirements
- Recognized lipid names and correctly formatted input for the chosen mode.
- The quantitative CSV mode requires condition and sample identifiers.
Considerations
- Check which lipid names match the ontology before interpreting results.
- The selected background, rankings and identification confidence affect enrichment.
Access and documentation
Free hosted service without an account requirement. The FAQ excludes confidential or proprietary uploads; review the current terms before submitting data.
Evidence and review
Official service documentation and dedicated tool citation reviewed on 2026-09-11. Included for downstream MS lipidomics interpretation. No user dataset was uploaded or enrichment analysis run.
Core publications
Resource papers, direct updates and tool-specific methods. Selection policy.
- Molenaar MR, Jeucken A, Wassenaar TA, et al. LION/web: a web-based ontology enrichment tool for lipidomic data analysis. GigaScience 8, giz061 (2019). doi:10.1093/gigascience/giz061
Related tools
Entry history
Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.
- 2026-09-11 · First committed entry
Add lipid ontology and pathway interpretation tools
View change · Entry at this revision