Overview
TARDIS integrates chromatographic peaks for user-specified LC-MS targets and reports peak-quality metrics. It uses target masses/retention times, optional QC/internal-standard context and xcms-based retention correction through R and a GUI.
What can this tool do?
Common uses
- An R package for targeted raw-data integration in mass spectrometry, designed to extract and quantify user-specified signals directly from raw or converted data.
Scientific fit
Primary function
Quantification and targeted analysis
Other functions
Preprocessing and feature extraction
Analysis types
Targeted metabolomics
Data compatibility
Inputs
Raw instrument data, Compound list or annotations
Outputs
Feature or peak table
Input formats
Centroided mzML or MsExperiment plus CSV/Excel/R target tables
Output formats
Peak-area/intensity/quality tables and diagnostic EIC plots
Scope and considerations
Designed for
- An R package for targeted raw-data integration in mass spectrometry, designed to extract and quantify user-specified signals directly from raw or converted data.
Not designed for
- Untargeted discovery of every chromatographic feature or absolute concentration determination without a suitable calibration procedure.
Important requirements
- R/Bioconductor dependencies, centroided mzML or an appropriate MsExperiment object, and a target table with identifiers, m/z, expected RT and polarity; configure QC and batch positions when used.
Considerations
- Inspect EICs and target windows before full integration. Multiple overlapping scan windows must be analyzed separately as documented to avoid sawtooth chromatograms.
Access and documentation
GPL-3.0 source distribution. External datasets, dependent packages and any hosted routes retain their own terms; software operation was not tested.
License: GPL-3.0
Evidence and review
Enveda intake rechecked against official repository documentation, package/license metadata and primary publication identity on 2026-10-27. Editorial source review only; no software execution or independent benchmark. See docs/enveda-expansion-review-2026-10-27-batch2.md.
Core publications
Resource papers, direct updates and tool-specific methods. Selection policy.
- Automated Integration and Quality Assessment of Chromatographic Peaks in LC–MS-Based Metabolomics and Lipidomics Using TARDIS. Analytical Chemistry (2025). doi:10.1021/acs.analchem.5c00567
Related tools
Entry history
Changes to this catalogue entry, not the tool's software release history. Acceptance and editorial review are separate.
- 2026-10-27 · First committed entry
Add 24 reviewed Enveda tools in a separate second batch
View change · Entry at this revision